In elderly subjects, the average trough levels of levodopa at steady state after the cr tablet were about 2 fold higher than after the standard sinemet 163 vs.

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After taking this medicine for long periods of timesuch as a year or moresome people suddenly lose the ability to moveThis loss of movement may last from a few minutes to several hoursThe person is then able to move as beforeThis condition may unexpectedly occur again and againThis problem is called theon-offeffectYour doctor may prescribe you a stronger dose of SINEMET or may ask you to take it more frequentlyYour doctor may need to prescribe you a different medicine.

SINEMET should be administered cautiously to patients with severe cardiovascular or pulmonary diseasebronchial asthmarenalhepatic or endocrine disease.

Nonselective monoamine oxidaseMAOinhibitors are contraindicated for use with SINEMETThese inhibitors must be discontinued at least two weeks prior to initiating therapy with SINEMETSINEMET may be administered concomitantly with the manufacturer’s recommended dose of an MAO inhibitor with selectivity for MAO type Be.gselegiline HClsee DRUG INTERACTIONS

Dopamine D2 receptor antagonistse.gphenothiazinesbutyrophenonesrisperidoneand isoniazid may reduce the therapeutic effects of levodopaIn additionthe beneficial effects of levodopa in Parkinson’s disease have been reported to be reversed by phenytoin and papaverinePatients taking these drugs with SINEMET should be carefully observed for loss of therapeutic response.

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do not drive, operate machinery, or do other activities until you know how sinemet sr affects you.